269066

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1721826..1723585 Replicon chromosome
Accession NZ_CP116600
Organism Burkholderia pseudomallei strain MSHR5089

Toxin (Protein)


Gene name hipA Uniprot ID Q63JY0
Locus tag AQ936_RS07385 Protein ID WP_004188815.1
Coordinates 1721826..1723178 (-) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C4I768
Locus tag AQ936_RS07390 Protein ID WP_004536731.1
Coordinates 1723175..1723585 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ936_RS07360 (AQ936_007360) 1718178..1718519 - 342 WP_004525272.1 hypothetical protein -
AQ936_RS07365 (AQ936_007365) 1718790..1719743 - 954 WP_004187785.1 agmatinase -
AQ936_RS07370 (AQ936_007370) 1719910..1720824 + 915 WP_045720445.1 LysR family transcriptional regulator -
AQ936_RS07375 (AQ936_007375) 1721015..1721161 + 147 WP_004199790.1 hypothetical protein -
AQ936_RS07380 (AQ936_007380) 1721262..1721669 + 408 WP_045720444.1 hypothetical protein -
AQ936_RS07385 (AQ936_007385) 1721826..1723178 - 1353 WP_004188815.1 type II toxin-antitoxin system HipA family toxin Toxin
AQ936_RS07390 (AQ936_007390) 1723175..1723585 - 411 WP_004536731.1 helix-turn-helix domain-containing protein Antitoxin
AQ936_RS07395 (AQ936_007395) 1723923..1724186 - 264 WP_004199789.1 hypothetical protein -
AQ936_RS07400 (AQ936_007400) 1724652..1727048 + 2397 WP_076842108.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
AQ936_RS07405 (AQ936_007405) 1727053..1728570 + 1518 WP_045720440.1 cellulose synthase complex periplasmic endoglucanase BcsZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49848.83 Da        Isoelectric Point: 9.6807

>T269066 WP_004188815.1 NZ_CP116600:c1723178-1721826 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14508.87 Da        Isoelectric Point: 11.8540

>AT269066 WP_004536731.1 NZ_CP116600:c1723585-1723175 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FSX2

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8KZI9

References