269065

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 177152..177689 Replicon chromosome
Accession NZ_CP116600
Organism Burkholderia pseudomallei strain MSHR5089

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag AQ936_RS00700 Protein ID WP_009923450.1
Coordinates 177420..177689 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag AQ936_RS00695 Protein ID WP_004525420.1
Coordinates 177152..177436 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AQ936_RS00665 (AQ936_000665) 172260..173522 - 1263 WP_009975402.1 cytochrome c peroxidase -
AQ936_RS00670 (AQ936_000670) 173681..175141 - 1461 WP_038737257.1 metallophosphoesterase -
AQ936_RS00675 (AQ936_000675) 175388..175504 + 117 Protein_134 transposase -
AQ936_RS00680 (AQ936_000680) 175731..176123 - 393 Protein_135 IS110 family transposase -
AQ936_RS00685 (AQ936_000685) 176122..176505 - 384 Protein_136 integrase core domain-containing protein -
AQ936_RS00695 (AQ936_000695) 177152..177436 - 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
AQ936_RS00700 (AQ936_000700) 177420..177689 - 270 WP_009923450.1 BrnT family toxin Toxin
AQ936_RS00705 (AQ936_000705) 178260..178535 + 276 WP_004552388.1 bacteriophage protein Gp49 -
AQ936_RS00710 (AQ936_000710) 178545..178676 + 132 WP_009923452.1 bacteriophage protein Gp48 -
AQ936_RS00715 (AQ936_000715) 178814..179056 + 243 WP_004545584.1 hypothetical protein -
AQ936_RS00720 (AQ936_000720) 179053..179211 + 159 WP_004549802.1 hypothetical protein -
AQ936_RS00725 (AQ936_000725) 179259..179477 + 219 WP_004552392.1 hypothetical protein -
AQ936_RS00730 (AQ936_000730) 179663..180316 - 654 WP_004545536.1 hypothetical protein -
AQ936_RS00735 (AQ936_000735) 180565..180714 + 150 WP_004537646.1 bacteriophage protein Gp44 -
AQ936_RS00740 (AQ936_000740) 180750..181283 + 534 Protein_146 SPFH domain-containing protein -
AQ936_RS00745 (AQ936_000745) 181482..181910 + 429 Protein_147 integrase core domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 170032..197807 27775


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10156.52 Da        Isoelectric Point: 7.1633

>T269065 WP_009923450.1 NZ_CP116600:c177689-177420 [Burkholderia pseudomallei]
MDITFDPTKNKTNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT269065 WP_004525420.1 NZ_CP116600:c177436-177152 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References