Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 887096..887667 Replicon chromosome
Accession NZ_CP116597
Organism Staphylococcus sp. NRL 22/194

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PNR82_RS04330 Protein ID WP_272108684.1
Coordinates 887263..887667 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PNR82_RS04325 Protein ID WP_243588913.1
Coordinates 887096..887266 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PNR82_RS04300 882914..883393 + 480 WP_243588909.1 PH domain-containing protein -
PNR82_RS04305 883386..884912 + 1527 WP_243588910.1 PH domain-containing protein -
PNR82_RS04310 884905..885399 + 495 WP_243603600.1 PH domain-containing protein -
PNR82_RS04315 885420..885779 + 360 WP_243588911.1 holo-ACP synthase -
PNR82_RS04320 885861..887009 + 1149 WP_243588912.1 alanine racemase -
PNR82_RS04325 887096..887266 + 171 WP_243588913.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PNR82_RS04330 887263..887667 + 405 WP_272108684.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PNR82_RS04335 887938..888939 + 1002 WP_243588915.1 PP2C family protein-serine/threonine phosphatase -
PNR82_RS04340 889031..889357 + 327 WP_243588916.1 anti-sigma factor antagonist -
PNR82_RS04345 889383..889835 + 453 WP_243590233.1 anti-sigma B factor RsbW -
PNR82_RS04350 889810..890580 + 771 WP_243588917.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15477.06 Da        Isoelectric Point: 9.8431

>T269062 WP_272108684.1 NZ_CP116597:887263-887667 [Staphylococcus sp. NRL 22/194]
MIKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYRLDRDSVILLEQIR
TLDKKRLKEKLTYLSEEKMKEVDEALDISLGLHEVRPQKLDYFMYKPNIYLIKR

Download         Length: 405 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6339.97 Da        Isoelectric Point: 4.0121

>AT269062 WP_243588913.1 NZ_CP116597:887096-887266 [Staphylococcus sp. NRL 22/194]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPLECEACDCNESYITSNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References