Detailed information of TA system TA269061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 876096..876607
• Replicon: chromosome
• Accession: NZ_CP116597
• Organism: Staphylococcus sp. NRL 22/194

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: PNR82_RS04270
• Protein ID: WP_243588902.1
• Coordinates: 876401..876607 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: PNR82_RS04265
• Protein ID: WP_103298014.1
• Coordinates: 876096..876389 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNR82_RS04245	871276..872147	+	872	Protein_836	membrane protein insertase YidC	-
PNR82_RS04250	872300..873615	+	1316	Protein_837	ISL3 family transposase	-
PNR82_RS04255	873705..874355	-	651	WP_243603599.1	HD domain-containing protein	-
PNR82_RS04260	874422..875907	-	1486	Protein_839	cardiolipin synthase	-
PNR82_RS04265	876096..876389	+	294	WP_103298014.1	copper-sensing transcriptional repressor CsoR	Antitoxin
PNR82_RS04270	876401..876607	+	207	WP_243588902.1	heavy-metal-associated domain-containing protein	Toxin
PNR82_RS04275	876717..876854	+	138	WP_243588903.1	Lmo0850 family protein	-
PNR82_RS04280	876899..878086	-	1188	WP_243588904.1	FtsW/RodA/SpoVE family cell cycle protein	-
PNR82_RS04285	878517..879588	+	1072	Protein_844	D-alanine--D-alanine ligase	-
PNR82_RS04290	879604..880959	+	1356	WP_243588906.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (16-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7783.72 Da
• Isoelectric Point: 4.2259

>T269061 WP_243588902.1 NZ_CP116597:876401-876607 [Staphylococcus sp. NRL 22/194]
MARSNVNIEGLNTNEQAEQLQHRLSQMIGVKEVIVSADYKIVEIEYETPTNLNSIEKEIYDDGFKVLN

Nucleotide

• Length: 207 bp

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11193.87 Da
• Isoelectric Point: 6.4769

>AT269061 WP_103298014.1 NZ_CP116597:876096-876389 [Staphylococcus sp. NRL 22/194]
MSSEIHAHHSEQMKLNLKSRLNRIEGQVRAINRMIEDDVYCDDVLTQIRATRSALNSVATKLLDYHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp