269060

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 33364..34501 Replicon plasmid pK205-4b-A
Accession NZ_CP116584
Organism Enterococcus dispar strain K205-4b

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag PML78_RS13410 Protein ID WP_271858591.1
Coordinates 33638..34501 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag PML78_RS13405 Protein ID WP_002326825.1
Coordinates 33364..33636 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML78_RS13375 (PML78_13375) 30375..30542 + 168 Protein_33 peptide-binding protein -
PML78_RS13380 (PML78_13380) 30665..30748 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
PML78_RS13385 (PML78_13385) 30873..31610 + 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
PML78_RS13390 (PML78_13390) 31780..32040 + 261 Protein_36 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
PML78_RS13395 (PML78_13395) 32143..33039 + 897 WP_014862451.1 ParA family protein -
PML78_RS13400 (PML78_13400) 33138..33347 + 210 WP_000527318.1 peptide-binding protein -
PML78_RS13405 (PML78_13405) 33364..33636 + 273 WP_002326825.1 antitoxin Antitoxin
PML78_RS13410 (PML78_13410) 33638..34501 + 864 WP_271858591.1 zeta toxin family protein Toxin
PML78_RS13415 (PML78_13415) 34939..35436 + 498 WP_271858592.1 molecular chaperone DnaJ -
PML78_RS13420 (PML78_13420) 35470..35775 + 306 WP_271858593.1 hypothetical protein -
PML78_RS13425 (PML78_13425) 35798..36055 - 258 WP_000002668.1 hypothetical protein -
PML78_RS13430 (PML78_13430) 36058..36357 - 300 WP_271858595.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid erm(B) - 1..38374 38374


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-214)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32687.33 Da        Isoelectric Point: 7.3939

>T269060 WP_271858591.1 NZ_CP116584:33638-34501 [Enterococcus dispar]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKYVTPYSNRMTEAIISRLRDKGYNLVIEGTGRTTDVPIQTATMLQAKDYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKIPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT269060 WP_002326825.1 NZ_CP116584:33364-33636 [Enterococcus dispar]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References