Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 1090411..1090930 Replicon chromosome
Accession NZ_CP116581
Organism Enterococcus durans strain R59-1

Toxin (Protein)


Gene name Txe Uniprot ID A0A377L4K5
Locus tag PML98_RS04940 Protein ID WP_005878588.1
Coordinates 1090673..1090930 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A367CD15
Locus tag PML98_RS04935 Protein ID WP_005878590.1
Coordinates 1090411..1090680 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML98_RS04905 (PML98_04905) 1085545..1086432 + 888 WP_271852924.1 site-specific tyrosine recombinase XerD -
PML98_RS04910 (PML98_04910) 1086451..1086822 + 372 WP_005878601.1 GNAT family N-acetyltransferase -
PML98_RS04915 (PML98_04915) 1086819..1087589 + 771 WP_025479929.1 segregation/condensation protein A -
PML98_RS04920 (PML98_04920) 1087573..1088148 + 576 WP_005878596.1 SMC-Scp complex subunit ScpB -
PML98_RS04925 (PML98_04925) 1088148..1088864 + 717 WP_005878594.1 pseudouridine synthase -
PML98_RS04930 (PML98_04930) 1089196..1089804 + 609 WP_005878592.1 ECF transporter S component -
PML98_RS04935 (PML98_04935) 1090411..1090680 + 270 WP_005878590.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML98_RS04940 (PML98_04940) 1090673..1090930 + 258 WP_005878588.1 Txe/YoeB family addiction module toxin Toxin
PML98_RS04945 (PML98_04945) 1091295..1091894 + 600 WP_271852926.1 hypothetical protein -
PML98_RS04950 (PML98_04950) 1091909..1092355 + 447 WP_271852927.1 hypothetical protein -
PML98_RS04955 (PML98_04955) 1093050..1094573 + 1524 WP_005878582.1 YfcC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10274.61 Da        Isoelectric Point: 9.2515

>T269057 WP_005878588.1 NZ_CP116581:1090673-1090930 [Enterococcus durans]
MIKAWSDDAWNDYLYWYEQGNKSNIKKINKLIKDIDRSPFNGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10402.60 Da        Isoelectric Point: 4.7051

>AT269057 WP_005878590.1 NZ_CP116581:1090411-1090680 [Enterococcus durans]
MEAVSYSNFRKNLRGYMKQVNEDAETLIVTSKDVDDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGTFKKH
DLIEVESDD

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377L4K5

Antitoxin

Source ID Structure
AlphaFold DB A0A367CD15

References