Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2336345..2336952 Replicon chromosome
Accession NZ_CP116579
Organism Enterococcus durans strain R109-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PML92_RS10890 Protein ID WP_193808921.1
Coordinates 2336345..2336695 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PML92_RS10895 Protein ID WP_081134844.1
Coordinates 2336689..2336952 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML92_RS10870 (PML92_10870) 2332070..2332885 - 816 WP_113846130.1 Cof-type HAD-IIB family hydrolase -
PML92_RS10875 (PML92_10875) 2332882..2333571 - 690 WP_005878253.1 N-acetylmannosamine-6-phosphate 2-epimerase -
PML92_RS10880 (PML92_10880) 2334198..2334447 + 250 Protein_2139 TPM domain-containing protein -
PML92_RS10885 (PML92_10885) 2334671..2336146 + 1476 WP_271847677.1 metallophosphoesterase -
PML92_RS10890 (PML92_10890) 2336345..2336695 - 351 WP_193808921.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML92_RS10895 (PML92_10895) 2336689..2336952 - 264 WP_081134844.1 PbsX family transcriptional regulator Antitoxin
PML92_RS10900 (PML92_10900) 2337296..2337970 - 675 WP_226103608.1 Crp/Fnr family transcriptional regulator -
PML92_RS10905 (PML92_10905) 2338145..2338423 + 279 WP_005878249.1 hypothetical protein -
PML92_RS10910 (PML92_10910) 2338442..2339629 + 1188 WP_193808922.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13240.26 Da        Isoelectric Point: 8.8202

>T269055 WP_193808921.1 NZ_CP116579:c2336695-2336345 [Enterococcus durans]
MVRNPRQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVTVAPISSTTRNYPLYVNINSKYEMKTTGKVLLDQLT
TIDYEARECIFLEKAHDSLVEELLMKVRTVFQKVSK

Download         Length: 351 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10171.55 Da        Isoelectric Point: 4.6865

>AT269055 WP_081134844.1 NZ_CP116579:c2336952-2336689 [Enterococcus durans]
MEMLPIKKWGNSNGLRLPKYIMEYLGIHTEDKVKITQEEVNGQKRLIIEAANLENELTIEQLFENYTDERNHVTIQNLGE
AVGNEKW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References