Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 178411..179021 | Replicon | chromosome |
Accession | NZ_CP116579 | ||
Organism | Enterococcus durans strain R109-1 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | - |
Locus tag | PML92_RS00870 | Protein ID | WP_171024540.1 |
Coordinates | 178411..178599 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | PML92_RS00875 | Protein ID | WP_081133751.1 |
Coordinates | 178635..179021 (+) | Length | 129 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PML92_RS00860 (PML92_00860) | 175317..177407 | + | 2091 | WP_193809443.1 | DNA mismatch repair endonuclease MutL | - |
PML92_RS00865 (PML92_00865) | 177426..177983 | + | 558 | WP_193809444.1 | Maf family protein | - |
PML92_RS00870 (PML92_00870) | 178411..178599 | + | 189 | WP_171024540.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
PML92_RS00875 (PML92_00875) | 178635..179021 | + | 387 | WP_081133751.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
PML92_RS00880 (PML92_00880) | 179338..181323 | - | 1986 | WP_193809445.1 | PTS system trehalose-specific EIIBC component | - |
PML92_RS00885 (PML92_00885) | 181560..182273 | + | 714 | WP_005875275.1 | trehalose operon repressor | - |
PML92_RS00890 (PML92_00890) | 182350..182790 | + | 441 | WP_005875277.1 | peptide-methionine (R)-S-oxide reductase MsrB | - |
PML92_RS00895 (PML92_00895) | 183403..184005 | + | 603 | WP_005875279.1 | Holliday junction branch migration protein RuvA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7019.35 Da Isoelectric Point: 11.0638
>T269052 WP_171024540.1 NZ_CP116579:178411-178599 [Enterococcus durans]
MPMTIREAKKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL
MPMTIREAKKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL
Download Length: 189 bp
Antitoxin
Download Length: 129 a.a. Molecular weight: 14289.47 Da Isoelectric Point: 4.3660
>AT269052 WP_081133751.1 NZ_CP116579:178635-179021 [Enterococcus durans]
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI
Download Length: 387 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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