Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 178411..179021 Replicon chromosome
Accession NZ_CP116579
Organism Enterococcus durans strain R109-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PML92_RS00870 Protein ID WP_171024540.1
Coordinates 178411..178599 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PML92_RS00875 Protein ID WP_081133751.1
Coordinates 178635..179021 (+) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML92_RS00860 (PML92_00860) 175317..177407 + 2091 WP_193809443.1 DNA mismatch repair endonuclease MutL -
PML92_RS00865 (PML92_00865) 177426..177983 + 558 WP_193809444.1 Maf family protein -
PML92_RS00870 (PML92_00870) 178411..178599 + 189 WP_171024540.1 type II toxin-antitoxin system HicA family toxin Toxin
PML92_RS00875 (PML92_00875) 178635..179021 + 387 WP_081133751.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PML92_RS00880 (PML92_00880) 179338..181323 - 1986 WP_193809445.1 PTS system trehalose-specific EIIBC component -
PML92_RS00885 (PML92_00885) 181560..182273 + 714 WP_005875275.1 trehalose operon repressor -
PML92_RS00890 (PML92_00890) 182350..182790 + 441 WP_005875277.1 peptide-methionine (R)-S-oxide reductase MsrB -
PML92_RS00895 (PML92_00895) 183403..184005 + 603 WP_005875279.1 Holliday junction branch migration protein RuvA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-103)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7019.35 Da        Isoelectric Point: 11.0638

>T269052 WP_171024540.1 NZ_CP116579:178411-178599 [Enterococcus durans]
MPMTIREAKKLLKEAGFVEVKGGKGSHRKFIKENFPRPVILTCHSKELSQRVENTVRKAVGL

Download         Length: 189 bp

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14289.47 Da        Isoelectric Point: 4.3660

>AT269052 WP_081133751.1 NZ_CP116579:178635-179021 [Enterococcus durans]
MKKVYPAIFEKDPVGYGIYFPDVEGAVTQAETILEGLEVASDALGIMLGDLVERNLPLPEPSTMKEISYDPETEFATLVS
VELDDYLKDVKLDKKTIKIPHWLNVRATNEGINFSKTMTEALAKKLNI

Download         Length: 387 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References