Detailed information of TA system TA026903

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384642..1385330
• Replicon: chromosome
• Accession: NC_017524
• Organism: Mycobacterium tuberculosis CTRI-2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: MTCTRI2_RS06590
• Protein ID: WP_003406304.1
• Coordinates: 1384899..1385330 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: MTCTRI2_RS06585
• Protein ID: WP_003406302.1
• Coordinates: 1384642..1384902 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTCTRI2_RS06565	1380219..1381043	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
MTCTRI2_RS06570	1381048..1382229	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
MTCTRI2_RS06575	1382306..1383406	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
MTCTRI2_RS06580	1383577..1384566	+	990	WP_003406301.1	malate dehydrogenase	-
MTCTRI2_RS06585	1384642..1384902	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
MTCTRI2_RS06590	1384899..1385330	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
MTCTRI2_RS06595	1385353..1387041	-	1689	WP_003910308.1	PE family protein	-
MTCTRI2_RS06600	1387221..1388081	+	861	WP_003900301.1	hypothetical protein	-
MTCTRI2_RS06605	1388162..1388992	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
MTCTRI2_RS06610	1389049..1389342	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
MTCTRI2_RS06615	1389339..1389608	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T26903 WP_003406304.1 NC_017524:1384899-1385330 [Mycobacterium tuberculosis CTRI-2]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T26903 NC_017524:1384899-1385330 [Mycobacterium tuberculosis CTRI-2]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT26903 WP_003406302.1 NC_017524:1384642-1384902 [Mycobacterium tuberculosis CTRI-2]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT26903 NC_017524:1384642-1384902 [Mycobacterium tuberculosis CTRI-2]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6