Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2821794..2822365 Replicon chromosome
Accession NZ_CP116571
Organism Enterococcus faecalis strain K190-1

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PML73_RS13930 Protein ID WP_002360937.1
Coordinates 2821794..2822135 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PML73_RS13935 Protein ID WP_002367500.1
Coordinates 2822135..2822365 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML73_RS13925 (2817809) 2817809..2821423 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PML73_RS13930 (2821794) 2821794..2822135 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML73_RS13935 (2822135) 2822135..2822365 - 231 WP_002367500.1 hypothetical protein Antitoxin
PML73_RS13940 (2822420) 2822420..2822599 - 180 WP_111997057.1 hypothetical protein -
PML73_RS13945 (2822779) 2822779..2822994 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML73_RS13950 (2823133) 2823133..2824125 + 993 WP_002389493.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML73_RS13955 (2824389) 2824389..2825027 - 639 WP_271865427.1 lytic polysaccharide monooxygenase -
PML73_RS13960 (2825713) 2825713..2827329 + 1617 WP_002389442.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T269014 WP_002360937.1 NZ_CP116571:c2822135-2821794 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT269014 WP_002367500.1 NZ_CP116571:c2822365-2822135 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References