269000

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 454365..454947 Replicon chromosome
Accession NZ_CP116571
Organism Enterococcus faecalis strain K190-1

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag PML73_RS02395 Protein ID WP_002355414.1
Coordinates 454639..454947 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag PML73_RS02390 Protein ID WP_002326825.1
Coordinates 454365..454637 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML73_RS02360 (449646) 449646..450374 - 729 WP_002355404.1 GntR family transcriptional regulator -
PML73_RS02365 (450551) 450551..451477 + 927 WP_002355406.1 hypothetical protein -
PML73_RS02370 (451494) 451494..452777 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
PML73_RS02375 (452969) 452969..453091 + 123 Protein_443 topoisomerase -
PML73_RS02380 (453166) 453166..454062 + 897 WP_002363034.1 ParA family protein -
PML73_RS02385 (454139) 454139..454348 + 210 WP_002363035.1 peptide-binding protein -
PML73_RS02390 (454365) 454365..454637 + 273 WP_002326825.1 antitoxin Antitoxin
PML73_RS02395 (454639) 454639..454947 + 309 WP_002355414.1 zeta toxin family protein Toxin
PML73_RS02400 (455027) 455027..455434 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
PML73_RS02405 (455501) 455501..456001 - 501 WP_002363039.1 HAD family hydrolase -
PML73_RS02410 (456006) 456006..456773 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
PML73_RS02415 (457260) 457260..457685 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
PML73_RS02420 (457702) 457702..458217 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
PML73_RS02425 (458228) 458228..459160 + 933 WP_002363040.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T269000 WP_002355414.1 NZ_CP116571:454639-454947 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT269000 WP_002326825.1 NZ_CP116571:454365-454637 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References