Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2624136..2624707 Replicon chromosome
Accession NZ_CP116569
Organism Enterococcus faecalis strain K198-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PML91_RS12475 Protein ID WP_002354774.1
Coordinates 2624136..2624477 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PML91_RS12480 Protein ID WP_002354773.1
Coordinates 2624477..2624707 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML91_RS12470 (2620151) 2620151..2623765 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PML91_RS12475 (2624136) 2624136..2624477 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML91_RS12480 (2624477) 2624477..2624707 - 231 WP_002354773.1 hypothetical protein Antitoxin
PML91_RS12485 (2625121) 2625121..2625336 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML91_RS12490 (2625475) 2625475..2626467 + 993 WP_002354765.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML91_RS12495 (2626534) 2626534..2627166 - 633 WP_002358972.1 RloB family protein -
PML91_RS12500 (2627175) 2627175..2628470 - 1296 WP_176944748.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T268987 WP_002354774.1 NZ_CP116569:c2624477-2624136 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT268987 WP_002354773.1 NZ_CP116569:c2624707-2624477 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References