Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1015098..1015717 Replicon chromosome
Accession NC_017524
Organism Mycobacterium tuberculosis CTRI-2

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MTCTRI2_RS04810 Protein ID WP_003404726.1
Coordinates 1015283..1015717 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MTCTRI2_RS04805 Protein ID WP_003898641.1
Coordinates 1015098..1015277 (+) Length 60 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTCTRI2_RS04795 1010571..1012151 + 1581 WP_003909313.1 serine hydrolase -
MTCTRI2_RS04800 1012148..1014541 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
MTCTRI2_RS22370 1014814..1014972 + 159 WP_003404720.1 hypothetical protein -
MTCTRI2_RS04805 1015098..1015277 + 180 WP_003898641.1 antitoxin Antitoxin
MTCTRI2_RS04810 1015283..1015717 + 435 WP_003404726.1 SRPBCC family protein Toxin
MTCTRI2_RS04815 1015815..1016588 + 774 WP_003404735.1 VOC family protein -
MTCTRI2_RS04820 1016653..1017102 + 450 WP_003404738.1 hypothetical protein -
MTCTRI2_RS04825 1017237..1017467 - 231 WP_003898642.1 hypothetical protein -
MTCTRI2_RS04830 1017634..1019142 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
MTCTRI2_RS04835 1019144..1020382 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-142)

Antitoxin

(4-50)


Sequences


Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T26898 WP_003404726.1 NC_017524:1015283-1015717 [Mycobacterium tuberculosis CTRI-2]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T26898 NC_017524:1015283-1015717 [Mycobacterium tuberculosis CTRI-2]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT26898 WP_003898641.1 NC_017524:1015098-1015277 [Mycobacterium tuberculosis CTRI-2]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT26898 NC_017524:1015098-1015277 [Mycobacterium tuberculosis CTRI-2]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References