268974

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2673776..2674347 Replicon chromosome
Accession NZ_CP116566
Organism Enterococcus faecalis strain K191-1

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PML79_RS12930 Protein ID WP_002360937.1
Coordinates 2673776..2674117 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PML79_RS12935 Protein ID WP_002367500.1
Coordinates 2674117..2674347 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML79_RS12925 (2669536) 2669536..2673150 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PML79_RS12930 (2673776) 2673776..2674117 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML79_RS12935 (2674117) 2674117..2674347 - 231 WP_002367500.1 hypothetical protein Antitoxin
PML79_RS12940 (2674761) 2674761..2674976 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML79_RS12945 (2675115) 2675115..2676107 + 993 WP_010776203.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML79_RS12950 (2676174) 2676174..2676560 - 387 WP_244323692.1 RloB domain-containing protein -
PML79_RS12955 (2676512) 2676512..2676790 - 279 WP_253544428.1 RloB family protein -
PML79_RS12960 (2676799) 2676799..2678094 - 1296 WP_010824051.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T268974 WP_002360937.1 NZ_CP116566:c2674117-2673776 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT268974 WP_002367500.1 NZ_CP116566:c2674347-2674117 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References