268952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2723936..2724507 Replicon chromosome
Accession NZ_CP116564
Organism Enterococcus faecalis strain K188-1

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PML72_RS13325 Protein ID WP_002360937.1
Coordinates 2723936..2724277 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S4CGQ1
Locus tag PML72_RS13330 Protein ID WP_002367500.1
Coordinates 2724277..2724507 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML72_RS13320 (2719696) 2719696..2723310 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
PML72_RS13325 (2723936) 2723936..2724277 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML72_RS13330 (2724277) 2724277..2724507 - 231 WP_002367500.1 hypothetical protein Antitoxin
PML72_RS13335 (2724921) 2724921..2725136 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML72_RS13340 (2725275) 2725275..2726267 + 993 WP_010776203.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML72_RS13345 (2726334) 2726334..2726720 - 387 WP_244323692.1 RloB domain-containing protein -
PML72_RS13350 (2726672) 2726672..2726950 - 279 WP_253544428.1 RloB family protein -
PML72_RS13355 (2726959) 2726959..2728254 - 1296 WP_010824051.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T268952 WP_002360937.1 NZ_CP116564:c2724277-2723936 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.69 Da        Isoelectric Point: 4.3313

>AT268952 WP_002367500.1 NZ_CP116564:c2724507-2724277 [Enterococcus faecalis]
MLTTKSRRQGNSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB S4CGQ1

References