Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 34641..35175 Replicon plasmid pK72-1-B
Accession NZ_CP116563
Organism Enterococcus faecalis strain K72-1

Toxin (Protein)


Gene name relE Uniprot ID R3JX52
Locus tag PML97_RS14385 Protein ID WP_002360769.1
Coordinates 34900..35175 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag PML97_RS14380 Protein ID WP_002369771.1
Coordinates 34641..34907 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML97_RS14350 (PML97_14350) 30744..31529 + 786 WP_000803546.1 winged helix-turn-helix domain-containing protein -
PML97_RS14355 (PML97_14355) 31535..32023 + 489 WP_002368088.1 hypothetical protein -
PML97_RS14360 (PML97_14360) 32615..32881 + 267 WP_002368091.1 hypothetical protein -
PML97_RS14365 (PML97_14365) 32914..33408 + 495 WP_002368092.1 DnaJ domain-containing protein -
PML97_RS14370 (PML97_14370) 33506..33922 + 417 WP_002368093.1 single-stranded DNA-binding protein -
PML97_RS14375 (PML97_14375) 33946..34530 + 585 WP_002368095.1 thermonuclease family protein -
PML97_RS14380 (PML97_14380) 34641..34907 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PML97_RS14385 (PML97_14385) 34900..35175 + 276 WP_002360769.1 type II toxin-antitoxin system YafQ family toxin Toxin
PML97_RS14390 (PML97_14390) 35978..36163 + 186 WP_002368099.1 hypothetical protein -
PML97_RS14395 (PML97_14395) 36148..36339 + 192 WP_002401572.1 DpnD/PcfM family protein -
PML97_RS14400 (PML97_14400) 36570..37349 + 780 WP_002402212.1 Cas9 inhibitor AcrIIA9 family protein -
PML97_RS14405 (PML97_14405) 37349..38608 + 1260 WP_002402213.1 PcfJ domain-containing protein -
PML97_RS14410 (PML97_14410) 39258..39986 + 729 WP_002402215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - prgB/asc10 1..61461 61461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-86)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10732.58 Da        Isoelectric Point: 9.6918

>T268934 WP_002360769.1 NZ_CP116563:34900-35175 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKEVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9772.09 Da        Isoelectric Point: 4.4791

>AT268934 WP_002369771.1 NZ_CP116563:34641-34907 [Enterococcus faecalis]
VATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AEA7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References