268875

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2656655..2657226 Replicon chromosome
Accession NZ_CP116555
Organism Enterococcus faecalis strain K70-12a

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PML75_RS12570 Protein ID WP_002360937.1
Coordinates 2656655..2656996 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PML75_RS12575 Protein ID WP_002354773.1
Coordinates 2656996..2657226 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML75_RS12565 (2652670) 2652670..2656284 - 3615 WP_010712913.1 DNA-directed RNA polymerase subunit beta -
PML75_RS12570 (2656655) 2656655..2656996 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML75_RS12575 (2656996) 2656996..2657226 - 231 WP_002354773.1 hypothetical protein Antitoxin
PML75_RS12580 (2657400) 2657400..2657615 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML75_RS12585 (2657754) 2657754..2658746 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML75_RS12590 (2659050) 2659050..2659688 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
PML75_RS12595 (2660375) 2660375..2661991 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T268875 WP_002360937.1 NZ_CP116555:c2656996-2656655 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT268875 WP_002354773.1 NZ_CP116555:c2657226-2656996 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References