268859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2616413..2616984 Replicon chromosome
Accession NZ_CP116553
Organism Enterococcus faecalis strain K80-2b

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag PML81_RS12260 Protein ID WP_002360937.1
Coordinates 2616413..2616754 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag PML81_RS12265 Protein ID WP_002354773.1
Coordinates 2616754..2616984 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML81_RS12255 (2612428) 2612428..2616042 - 3615 WP_010712913.1 DNA-directed RNA polymerase subunit beta -
PML81_RS12260 (2616413) 2616413..2616754 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML81_RS12265 (2616754) 2616754..2616984 - 231 WP_002354773.1 hypothetical protein Antitoxin
PML81_RS12270 (2617158) 2617158..2617373 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
PML81_RS12275 (2617512) 2617512..2618504 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
PML81_RS12280 (2618808) 2618808..2619446 - 639 WP_002375448.1 lytic polysaccharide monooxygenase -
PML81_RS12285 (2620133) 2620133..2621749 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T268859 WP_002360937.1 NZ_CP116553:c2616754-2616413 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT268859 WP_002354773.1 NZ_CP116553:c2616984-2616754 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References