Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 509400..509971 Replicon chromosome
Accession NZ_CP116540
Organism Enterococcus faecium strain K75-1

Toxin (Protein)


Gene name mazF Uniprot ID Q3Y2B8
Locus tag PML93_RS02435 Protein ID WP_002286801.1
Coordinates 509630..509971 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag PML93_RS02430 Protein ID WP_002323011.1
Coordinates 509400..509630 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML93_RS02405 (PML93_02405) 504533..505864 + 1332 WP_002286818.1 FAD-containing oxidoreductase -
PML93_RS02410 (PML93_02410) 505886..506512 + 627 WP_002286816.1 cysteine hydrolase -
PML93_RS02415 (PML93_02415) 506695..507276 + 582 WP_002286813.1 TetR/AcrR family transcriptional regulator -
PML93_RS02420 (PML93_02420) 508008..508570 + 563 Protein_480 SOS response-associated peptidase family protein -
PML93_RS02425 (PML93_02425) 508775..509113 - 339 WP_002286804.1 hypothetical protein -
PML93_RS02430 (PML93_02430) 509400..509630 + 231 WP_002323011.1 hypothetical protein Antitoxin
PML93_RS02435 (PML93_02435) 509630..509971 + 342 WP_002286801.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML93_RS02440 (PML93_02440) 510821..511006 + 186 WP_002304207.1 hypothetical protein -
PML93_RS02445 (PML93_02445) 511511..511705 + 195 WP_002297028.1 hypothetical protein -
PML93_RS02450 (PML93_02450) 511896..512145 + 250 Protein_486 transposase -
PML93_RS02455 (PML93_02455) 512389..513219 - 831 WP_002286789.1 manganese catalase family protein -
PML93_RS02460 (PML93_02460) 513427..514761 + 1335 WP_002286788.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13302.68 Da        Isoelectric Point: 9.9044

>T268836 WP_002286801.1 NZ_CP116540:509630-509971 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIITQ
LKSLDFKERKLKKIENLPLQDMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT268836 WP_002323011.1 NZ_CP116540:509400-509630 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FD66

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References