Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1140812..1141305 | Replicon | chromosome |
Accession | NZ_CP116536 | ||
Organism | Enterococcus faecium strain K162-1 |
Toxin (Protein)
Gene name | relE | Uniprot ID | J6KIM0 |
Locus tag | PML70_RS05500 | Protein ID | WP_002400299.1 |
Coordinates | 1141039..1141305 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A829AAJ0 |
Locus tag | PML70_RS05495 | Protein ID | WP_002329324.1 |
Coordinates | 1140812..1141042 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PML70_RS05470 (PML70_05470) | 1137079..1137255 | + | 177 | WP_179189389.1 | hypothetical protein | - |
PML70_RS05475 (PML70_05475) | 1137277..1138473 | + | 1197 | WP_113850551.1 | PIN-like domain-containing protein | - |
PML70_RS05485 (PML70_05485) | 1139751..1139999 | + | 249 | WP_010728305.1 | hypothetical protein | - |
PML70_RS05490 (PML70_05490) | 1140054..1140680 | - | 627 | WP_010728306.1 | ImmA/IrrE family metallo-endopeptidase | - |
PML70_RS05495 (PML70_05495) | 1140812..1141042 | + | 231 | WP_002329324.1 | DUF6290 family protein | Antitoxin |
PML70_RS05500 (PML70_05500) | 1141039..1141305 | + | 267 | WP_002400299.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
PML70_RS05505 (PML70_05505) | 1141678..1142844 | + | 1167 | WP_010728307.1 | radical SAM family heme chaperone HemW | - |
PML70_RS05510 (PML70_05510) | 1143078..1144121 | + | 1044 | WP_002289532.1 | heat-inducible transcriptional repressor HrcA | - |
PML70_RS05515 (PML70_05515) | 1144215..1144778 | + | 564 | WP_002296525.1 | nucleotide exchange factor GrpE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A4Y3JQ03 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829AAJ0 |