Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1140812..1141305 Replicon chromosome
Accession NZ_CP116536
Organism Enterococcus faecium strain K162-1

Toxin (Protein)


Gene name relE Uniprot ID J6KIM0
Locus tag PML70_RS05500 Protein ID WP_002400299.1
Coordinates 1141039..1141305 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag PML70_RS05495 Protein ID WP_002329324.1
Coordinates 1140812..1141042 (+) Length 77 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML70_RS05470 (PML70_05470) 1137079..1137255 + 177 WP_179189389.1 hypothetical protein -
PML70_RS05475 (PML70_05475) 1137277..1138473 + 1197 WP_113850551.1 PIN-like domain-containing protein -
PML70_RS05485 (PML70_05485) 1139751..1139999 + 249 WP_010728305.1 hypothetical protein -
PML70_RS05490 (PML70_05490) 1140054..1140680 - 627 WP_010728306.1 ImmA/IrrE family metallo-endopeptidase -
PML70_RS05495 (PML70_05495) 1140812..1141042 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
PML70_RS05500 (PML70_05500) 1141039..1141305 + 267 WP_002400299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PML70_RS05505 (PML70_05505) 1141678..1142844 + 1167 WP_010728307.1 radical SAM family heme chaperone HemW -
PML70_RS05510 (PML70_05510) 1143078..1144121 + 1044 WP_002289532.1 heat-inducible transcriptional repressor HrcA -
PML70_RS05515 (PML70_05515) 1144215..1144778 + 564 WP_002296525.1 nucleotide exchange factor GrpE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10642.41 Da        Isoelectric Point: 10.4982

>T268833 WP_002400299.1 NZ_CP116536:1141039-1141305 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQAMLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDKQLVVIAIQV
GHRRNIYD

Download         Length: 267 bp


Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT268833 WP_002329324.1 NZ_CP116536:1140812-1141042 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4Y3JQ03


Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References