Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 198952..199481 Replicon chromosome
Accession NZ_CP116536
Organism Enterococcus faecium strain K162-1

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag PML70_RS00985 Protein ID WP_002294198.1
Coordinates 199215..199481 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag PML70_RS00980 Protein ID WP_002294199.1
Coordinates 198952..199215 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML70_RS00965 (PML70_00965) 195362..196807 + 1446 WP_010728001.1 alpha-N-arabinofuranosidase -
PML70_RS00970 (PML70_00970) 196812..197078 + 267 WP_002315578.1 DUF6171 family protein -
PML70_RS00975 (PML70_00975) 197131..198321 + 1191 WP_010728002.1 arabinan endo-1,5-alpha-L-arabinosidase -
PML70_RS00980 (PML70_00980) 198952..199215 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML70_RS00985 (PML70_00985) 199215..199481 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
PML70_RS00990 (PML70_00990) 199682..200170 + 489 WP_010728003.1 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase -
PML70_RS00995 (PML70_00995) 200711..201382 - 672 WP_010728004.1 ABC transporter permease -
PML70_RS01000 (PML70_01000) 201379..202296 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
PML70_RS01005 (PML70_01005) 202293..202934 - 642 WP_002293405.1 ABC transporter permease -
PML70_RS01010 (PML70_01010) 202938..204113 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T268831 WP_002294198.1 NZ_CP116536:199215-199481 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT268831 WP_002294199.1 NZ_CP116536:198952-199215 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References