Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 188801..189330 Replicon chromosome
Accession NZ_CP116523
Organism Enterococcus faecium strain K69-1a

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag PML71_RS00940 Protein ID WP_002294198.1
Coordinates 189064..189330 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag PML71_RS00935 Protein ID WP_002294199.1
Coordinates 188801..189064 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML71_RS00920 (PML71_00920) 186176..187999 + 1824 WP_002294202.1 APC family permease -
PML71_RS00925 (PML71_00925) 188141..188326 - 186 WP_002294201.1 hypothetical protein -
PML71_RS00930 (PML71_00930) 188333..188461 + 129 WP_002294200.1 hypothetical protein -
PML71_RS00935 (PML71_00935) 188801..189064 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML71_RS00940 (PML71_00940) 189064..189330 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
PML71_RS00945 (PML71_00945) 189531..190019 + 489 WP_002337365.1 hypothetical protein -
PML71_RS00950 (PML71_00950) 190082..190249 + 168 WP_002294195.1 hypothetical protein -
PML71_RS00955 (PML71_00955) 190561..191232 - 672 WP_002319469.1 ABC transporter permease -
PML71_RS00960 (PML71_00960) 191229..192146 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
PML71_RS00965 (PML71_00965) 192143..192784 - 642 WP_002293405.1 ABC transporter permease -
PML71_RS00970 (PML71_00970) 192788..193963 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T268824 WP_002294198.1 NZ_CP116523:189064-189330 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT268824 WP_002294199.1 NZ_CP116523:188801-189064 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References