268822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 28733..29841 Replicon plasmid pR39-1-B
Accession NZ_CP116519
Organism Enterococcus faecium strain R39-1

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag PML88_RS13070 Protein ID WP_002328890.1
Coordinates 28733..29602 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag PML88_RS13075 Protein ID WP_000205227.1
Coordinates 29617..29841 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML88_RS13035 (PML88_13035) 23986..24549 - 564 Protein_29 recombinase zinc beta ribbon domain-containing protein -
PML88_RS13040 (PML88_13040) 24632..25090 + 459 WP_002325145.1 hypothetical protein -
PML88_RS13045 (PML88_13045) 25141..25431 - 291 WP_010733534.1 hypothetical protein -
PML88_RS13050 (PML88_13050) 25610..26419 - 810 WP_002294509.1 ANT(9) family aminoglycoside nucleotidyltransferase Spw -
PML88_RS13055 (PML88_13055) 26551..27078 - 528 WP_002294507.1 phosphoribosyltransferase family protein -
PML88_RS13060 (PML88_13060) 27122..27985 - 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
PML88_RS13065 (PML88_13065) 28018..28752 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
PML88_RS13070 (PML88_13070) 28733..29602 - 870 WP_002328890.1 nucleotidyltransferase domain-containing protein Toxin
PML88_RS13075 (PML88_13075) 29617..29841 - 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
PML88_RS13080 (PML88_13080) 29984..31546 - 1563 WP_000136908.1 recombinase family protein -
PML88_RS13085 (PML88_13085) 31548..31964 - 417 WP_000323438.1 recombinase -
PML88_RS13090 (PML88_13090) 31965..32462 - 498 WP_002327635.1 DNA recombinase -
PML88_RS13095 (PML88_13095) 32773..33102 - 330 Protein_41 DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32888.48 Da        Isoelectric Point: 4.8759

>T268822 WP_002328890.1 NZ_CP116519:c29602-28733 [Enterococcus faecium]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEHKPEKYTE
KVNHIFEVLGISLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT268822 WP_000205227.1 NZ_CP116519:c29841-29617 [Enterococcus faecium]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References