Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 75436..76007 Replicon plasmid pR39-1-A
Accession NZ_CP116518
Organism Enterococcus faecium strain R39-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PML88_RS12650 Protein ID WP_002322675.1
Coordinates 75666..76007 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PML88_RS12645 Protein ID WP_002322676.1
Coordinates 75436..75666 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML88_RS12620 (PML88_12620) 70508..71062 - 555 WP_002295761.1 tyrosine-type recombinase/integrase -
PML88_RS12625 (PML88_12625) 71805..72347 + 543 Protein_76 PHP domain-containing protein -
PML88_RS12630 (PML88_12630) 72398..73210 - 813 WP_002322679.1 AAA family ATPase -
PML88_RS12635 (PML88_12635) 73203..74639 - 1437 WP_002322678.1 Mu transposase C-terminal domain-containing protein -
PML88_RS12640 (PML88_12640) 74611..75204 - 594 WP_002322677.1 recombinase family protein -
PML88_RS12645 (PML88_12645) 75436..75666 + 231 WP_002322676.1 hypothetical protein Antitoxin
PML88_RS12650 (PML88_12650) 75666..76007 + 342 WP_002322675.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML88_RS12655 (PML88_12655) 76221..77723 - 1503 WP_002322674.1 xylulokinase -
PML88_RS12660 (PML88_12660) 77796..78848 - 1053 WP_002323515.1 sugar ABC transporter substrate-binding protein -
PML88_RS12665 (PML88_12665) 78901..79869 - 969 WP_002322672.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..122895 122895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13232.43 Da        Isoelectric Point: 9.4128

>T268821 WP_002322675.1 NZ_CP116518:75666-76007 [Enterococcus faecium]
MTEEKNYIPKKGDIVWIDFDPSAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIRNFPTRYSLPTELDTTGQILISQ
LKSLDFNERKLKKIESLPLQDMAKIDQMIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8551.48 Da        Isoelectric Point: 4.0070

>AT268821 WP_002322676.1 NZ_CP116518:75436-75666 [Enterococcus faecium]
MLITKSRLQGSSVVITLPSDNGKKPSENKEYIVIYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLSPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References