Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 485205..485776 Replicon chromosome
Accession NZ_CP116517
Organism Enterococcus faecium strain R39-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PML88_RS02290 Protein ID WP_224450759.1
Coordinates 485435..485776 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A828ZZN9
Locus tag PML88_RS02285 Protein ID WP_002323011.1
Coordinates 485205..485435 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML88_RS02260 (PML88_02260) 480682..482013 + 1332 WP_002300334.1 FAD-containing oxidoreductase -
PML88_RS02265 (PML88_02265) 482035..482661 + 627 WP_002300333.1 cysteine hydrolase -
PML88_RS02270 (PML88_02270) 482854..483435 + 582 WP_002300332.1 TetR/AcrR family transcriptional regulator -
PML88_RS02275 (PML88_02275) 483799..484374 + 576 WP_002302305.1 SOS response-associated peptidase family protein -
PML88_RS02280 (PML88_02280) 484579..484917 - 339 WP_002286804.1 hypothetical protein -
PML88_RS02285 (PML88_02285) 485205..485435 + 231 WP_002323011.1 hypothetical protein Antitoxin
PML88_RS02290 (PML88_02290) 485435..485776 + 342 WP_224450759.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PML88_RS02300 (PML88_02300) 488242..490745 + 2504 Protein_456 SpaA isopeptide-forming pilin-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13230.61 Da        Isoelectric Point: 10.0749

>T268820 WP_224450759.1 NZ_CP116517:485435-485776 [Enterococcus faecium]
VSEERIYIPKKGDIVWIDFDPSVGKEIQKRRPGLVVSRYEFNRKTMFSVICPITSTIKNLPTRYSLPEELDIKGQVIISQ
LKSLDFKERKLKKIENLPLQGMAKIDQIIQYMF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8523.39 Da        Isoelectric Point: 3.9078

>AT268820 WP_002323011.1 NZ_CP116517:485205-485435 [Enterococcus faecium]
MLVTKSRLQGSSVVVTLPSDNGKKPSENQEYIVVYSDDGTITLVPKIEDPFSGGEEAEYYEKDEWEDLTPEGREIL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZZN9

References