Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 199529..200058 Replicon chromosome
Accession NZ_CP116517
Organism Enterococcus faecium strain R39-1

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag PML88_RS00990 Protein ID WP_002294198.1
Coordinates 199792..200058 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag PML88_RS00985 Protein ID WP_002294199.1
Coordinates 199529..199792 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML88_RS00970 (PML88_00970) 195939..197384 + 1446 WP_219282475.1 alpha-N-arabinofuranosidase -
PML88_RS00975 (PML88_00975) 197389..197655 + 267 WP_002315578.1 DUF6171 family protein -
PML88_RS00980 (PML88_00980) 197708..198898 + 1191 WP_098188873.1 arabinan endo-1,5-alpha-L-arabinosidase -
PML88_RS00985 (PML88_00985) 199529..199792 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML88_RS00990 (PML88_00990) 199792..200058 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
PML88_RS00995 (PML88_00995) 200259..200747 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
PML88_RS01000 (PML88_01000) 201289..201960 - 672 WP_002319469.1 ABC transporter permease -
PML88_RS01005 (PML88_01005) 201957..202874 - 918 WP_002298332.1 osmoprotectant ABC transporter substrate-binding protein -
PML88_RS01010 (PML88_01010) 202871..203512 - 642 WP_002293405.1 ABC transporter permease -
PML88_RS01015 (PML88_01015) 203516..204691 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T268819 WP_002294198.1 NZ_CP116517:199792-200058 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT268819 WP_002294199.1 NZ_CP116517:199529-199792 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References