Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 198311..198840 Replicon chromosome
Accession NZ_CP116514
Organism Enterococcus faecium strain K195-6b

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag PML82_RS00990 Protein ID WP_002294198.1
Coordinates 198574..198840 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag PML82_RS00985 Protein ID WP_002294199.1
Coordinates 198311..198574 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML82_RS00975 (PML82_00975) 195687..197510 + 1824 WP_002294202.1 APC family permease -
PML82_RS00980 (PML82_00980) 197652..197837 - 186 WP_002294201.1 hypothetical protein -
PML82_RS00985 (PML82_00985) 198311..198574 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PML82_RS00990 (PML82_00990) 198574..198840 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
PML82_RS00995 (PML82_00995) 199041..199529 + 489 WP_002325212.1 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase -
PML82_RS01000 (PML82_01000) 200071..200742 - 672 WP_002319469.1 ABC transporter permease -
PML82_RS01005 (PML82_01005) 200739..201656 - 918 WP_002298332.1 osmoprotectant ABC transporter substrate-binding protein -
PML82_RS01010 (PML82_01010) 201653..202294 - 642 WP_002293405.1 ABC transporter permease -
PML82_RS01015 (PML82_01015) 202298..203473 - 1176 WP_002325214.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T268817 WP_002294198.1 NZ_CP116514:198574-198840 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT268817 WP_002294199.1 NZ_CP116514:198311-198574 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References