Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 20892..21385 Replicon plasmid pK136-2-B
Accession NZ_CP116505
Organism Vagococcus lutrae strain K136-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PML89_RS09730 Protein ID WP_272158274.1
Coordinates 20892..21164 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PML89_RS09735 Protein ID WP_272158275.1
Coordinates 21164..21385 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PML89_RS09715 (PML89_09715) 16743..18719 + 1977 WP_272158270.1 transketolase -
PML89_RS09720 (PML89_09720) 18947..19234 - 288 WP_272158272.1 hypothetical protein -
PML89_RS09725 (PML89_09725) 20182..20667 - 486 WP_272158273.1 hypothetical protein -
PML89_RS09730 (PML89_09730) 20892..21164 - 273 WP_272158274.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PML89_RS09735 (PML89_09735) 21164..21385 - 222 WP_272158275.1 DUF6290 family protein Antitoxin
PML89_RS09740 (PML89_09740) 21656..22006 - 351 Protein_23 transposase -
PML89_RS09745 (PML89_09745) 22169..22981 - 813 WP_272158276.1 LlaMI family restriction endonuclease -
PML89_RS09750 (PML89_09750) 23032..24132 - 1101 WP_272158277.1 DNA cytosine methyltransferase -
PML89_RS09755 (PML89_09755) 24136..24603 - 468 WP_272158278.1 hypothetical protein -
PML89_RS09760 (PML89_09760) 24719..25891 + 1173 WP_272158279.1 DNA (cytosine-5-)-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30144 30144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-89)

Antitoxin

Protein of unknown function DUF6290

(1-70)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10571.26 Da        Isoelectric Point: 10.7012

>T268815 WP_272158274.1 NZ_CP116505:c21164-20892 [Vagococcus lutrae]
MSKKYTVRYEKNAQKALKKMDKHQARLILSWISKNLEGTDSPRVHGKSLVGNKSGQWRYRIGDYRLLANINDETITILVL
EIGHRREIYK

Download         Length: 273 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8273.46 Da        Isoelectric Point: 4.2207

>AT268815 WP_272158275.1 NZ_CP116505:c21385-21164 [Vagococcus lutrae]
MSTVTFRVTDEEKSFIQAMADLNGLSLSELARTKLLEGLEDQIDMTLYEKAMKAHELKDESISHQDMLLELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References