Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/Txe-RelB
Location 572243..572750 Replicon chromosome
Accession NZ_CP116496
Organism MAG: Rickettsia asembonensis isolate Perak

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag PG979_RS03360 Protein ID WP_277360937.1
Coordinates 572243..572506 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H8K421
Locus tag PG979_RS03365 Protein ID WP_014391803.1
Coordinates 572499..572750 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG979_RS03330 (PG979_000668) 567720..567857 + 138 WP_277360932.1 hypothetical protein -
PG979_RS03335 (PG979_000669) 567841..568077 + 237 WP_277360933.1 hypothetical protein -
PG979_RS03340 (PG979_000670) 568155..568535 - 381 WP_277360934.1 hypothetical protein -
PG979_RS03345 (PG979_000671) 568633..570027 - 1395 WP_041077635.1 lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -
PG979_RS03350 (PG979_000672) 570024..570680 - 657 WP_277360935.1 lysophospholipid acyltransferase family protein -
PG979_RS03355 (PG979_000673) 570983..572182 - 1200 WP_277360936.1 pyridoxal phosphate-dependent aminotransferase -
PG979_RS03360 (PG979_000674) 572243..572506 - 264 WP_277360937.1 Txe/YoeB family addiction module toxin Toxin
PG979_RS03365 (PG979_000675) 572499..572750 - 252 WP_014391803.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PG979_RS03370 (PG979_000676) 572890..573888 + 999 WP_277360938.1 methyltransferase domain-containing protein -
PG979_RS03375 (PG979_000677) 573898..574653 + 756 WP_041077624.1 VacJ family lipoprotein -
PG979_RS03380 (PG979_000678) 574673..575272 + 600 WP_041077622.1 phospholipid-binding protein MlaC -
PG979_RS03385 (PG979_000679) 575593..576198 + 606 WP_277360939.1 transposase -
PG979_RS03390 (PG979_000680) 576147..576302 + 156 WP_277360940.1 transposase -
PG979_RS03395 576585..577145 + 561 WP_277361012.1 ribose-phosphate diphosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10469.25 Da        Isoelectric Point: 9.8255

>T268813 WP_277360937.1 NZ_CP116496:c572506-572243 [Rickettsia asembonensis]
MIEIESTLEAAEDLAYWKKYDIKKYERIKLLIKNIQEAPFTGIGKPEPLKHILSGLWSRRINHEHRLIYSVNPKQIIIYN
CRFHYKN

Download         Length: 264 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9521.77 Da        Isoelectric Point: 9.4884

>AT268813 WP_014391803.1 NZ_CP116496:c572750-572499 [Rickettsia asembonensis]
MNSISGTSFRKNLSSVLNTVENDHVPYLIKRKNHKNIILLTEEEYESTKETLYLLSNPANANRIKKSIEQAKRGEFAKVN
LDD

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2M0P5

References