Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 334627..335158 Replicon chromosome
Accession NZ_CP116496
Organism MAG: Rickettsia asembonensis isolate Perak

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PG979_RS02025 Protein ID WP_277360794.1
Coordinates 334877..335158 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A0C2LZV4
Locus tag PG979_RS02020 Protein ID WP_041078435.1
Coordinates 334627..334890 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG979_RS01990 (PG979_000395) 329967..330290 + 324 WP_011271665.1 YbaB/EbfC family nucleoid-associated protein -
PG979_RS01995 (PG979_000396) 330413..331108 - 696 WP_277360790.1 TIGR02281 family clan AA aspartic protease -
PG979_RS02000 (PG979_000397) 331247..332242 - 996 WP_277360791.1 serine hydrolase domain-containing protein -
PG979_RS02005 (PG979_000398) 332399..333121 - 723 WP_041078429.1 amino acid ABC transporter ATP-binding protein -
PG979_RS02010 (PG979_000399) 333125..333889 - 765 WP_277360792.1 MBL fold metallo-hydrolase -
PG979_RS02015 (PG979_000400) 333904..334566 + 663 WP_277360793.1 phosphatase PAP2 family protein -
PG979_RS02020 (PG979_000401) 334627..334890 + 264 WP_041078435.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PG979_RS02025 (PG979_000402) 334877..335158 + 282 WP_277360794.1 type II toxin-antitoxin system YafQ family toxin Toxin
PG979_RS02030 (PG979_000403) 335353..336435 + 1083 WP_041078439.1 LptF/LptG family permease -
PG979_RS02035 (PG979_000404) 336577..337041 - 465 WP_041078441.1 DNA polymerase III subunit chi -
PG979_RS02040 (PG979_000405) 337182..337775 - 594 WP_241773682.1 hypothetical protein -
PG979_RS02050 (PG979_000406) 338110..339276 - 1167 WP_277360795.1 succinyl-diaminopimelate desuccinylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11041.95 Da        Isoelectric Point: 10.2545

>T268812 WP_277360794.1 NZ_CP116496:334877-335158 [Rickettsia asembonensis]
MRTIKRTAQFKRDYKREKRRKHVINLDDILLKAVKYLIADTTLPVNMRDHALIGNWKDCRDCHIKPDLVLIYRKPDADTL
ELIRLGSHNELGF

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9550.05 Da        Isoelectric Point: 5.0916

>AT268812 WP_041078435.1 NZ_CP116496:334627-334890 [Rickettsia asembonensis]
MSADSIVRARINEDVKEEAALVLAAMGLTLSDAVRMLLFRVAREKALPFEPLIPNDETIKAMKAARSGKLVHVGNINNFL
SDLNEND

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LZV4

References