Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 108725..109284 Replicon chromosome
Accession NZ_CP116496
Organism MAG: Rickettsia asembonensis isolate Perak

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PG979_RS00780 Protein ID WP_277360678.1
Coordinates 108725..109054 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PG979_RS00785 Protein ID WP_041078961.1
Coordinates 109048..109284 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG979_RS00760 105637..105915 - 279 WP_199402805.1 transposase -
PG979_RS00765 105909..106431 + 523 Protein_115 transposase -
PG979_RS00770 (PG979_000157) 106582..107514 - 933 WP_277360676.1 transposase -
PG979_RS00775 (PG979_000158) 107902..108483 + 582 WP_277360677.1 hypothetical protein -
PG979_RS00780 (PG979_000159) 108725..109054 - 330 WP_277360678.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PG979_RS00785 (PG979_000160) 109048..109284 - 237 WP_041078961.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PG979_RS00790 (PG979_000161) 109360..110703 - 1344 WP_041078960.1 ribosome biogenesis GTPase Der -
PG979_RS00795 (PG979_000162) 110706..110971 - 266 Protein_121 SemiSWEET family sugar transporter -
PG979_RS00800 (PG979_000163) 111176..111958 - 783 WP_041078958.1 exodeoxyribonuclease III -
PG979_RS00805 (PG979_000164) 111955..112947 - 993 WP_277360679.1 hypothetical protein -
PG979_RS00810 (PG979_000165) 113092..113526 - 435 WP_277360680.1 transporter substrate-binding domain-containing protein -
PG979_RS00815 113660..113749 + 90 WP_277360996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 105909..106172 263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-108)

Antitoxin

Antitoxin PemI-like

(1-78)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12582.01 Da        Isoelectric Point: 10.0532

>T268811 WP_277360678.1 NZ_CP116496:c109054-108725 [Rickettsia asembonensis]
MVNYIPEKGDIVWLDFEPQKGKEIQKTRPAVVLSPYKYHLKSGLALFAPITSQIKNYPFEVIIDFQQIKGAVLCDQVRSM
DFKARKANKILTLNKILIDEIIHKLKLLL

Download         Length: 330 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8773.97 Da        Isoelectric Point: 8.7644

>AT268811 WP_041078961.1 NZ_CP116496:c109284-109048 [Rickettsia asembonensis]
MQSQIKKWGNSLGIRIPKHLAGKLHVSEGTLVNLKLVNNSLIISTEKSELDTLLDNITDSNRHHELLSNDKTKGNETW

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References