Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 31065..31708 Replicon plasmid unnamed3
Accession NZ_CP116494
Organism Klebsiella pneumoniae strain XY05-03

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag PIB23_RS29360 Protein ID WP_001044770.1
Coordinates 31065..31481 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag PIB23_RS29365 Protein ID WP_001261282.1
Coordinates 31478..31708 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB23_RS29340 (27168) 27168..27440 - 273 Protein_34 transposase -
PIB23_RS29350 (28422) 28422..29444 - 1023 WP_000361404.1 helicase UvrD -
PIB23_RS29355 (29429) 29429..30991 - 1563 WP_004206609.1 AAA family ATPase -
PIB23_RS29360 (31065) 31065..31481 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
PIB23_RS29365 (31478) 31478..31708 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIB23_RS29370 (31665) 31665..32126 + 462 WP_014343465.1 hypothetical protein -
PIB23_RS29375 (32287) 32287..33231 + 945 WP_011977810.1 hypothetical protein -
PIB23_RS29380 (33268) 33268..33660 + 393 WP_011977811.1 hypothetical protein -
PIB23_RS29385 (33718) 33718..34239 + 522 WP_013214008.1 hypothetical protein -
PIB23_RS29390 (34285) 34285..34488 + 204 WP_011977813.1 hypothetical protein -
PIB23_RS29395 (34518) 34518..35522 + 1005 WP_011977814.1 hypothetical protein -
PIB23_RS29400 (35706) 35706..36485 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaSHV-12 / blaKPC-2 / blaCTX-M-65 - 1..85083 85083


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T268806 WP_001044770.1 NZ_CP116494:c31481-31065 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT268806 WP_001261282.1 NZ_CP116494:c31708-31478 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References