Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 76393..76973 Replicon plasmid unnamed2
Accession NZ_CP116493
Organism Klebsiella pneumoniae strain XY05-03

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag PIB23_RS29045 Protein ID WP_071177730.1
Coordinates 76393..76707 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag PIB23_RS29050 Protein ID WP_000093040.1
Coordinates 76695..76973 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB23_RS29015 (PIB23_29015) 72074..72958 - 885 WP_000058717.1 EamA family transporter -
PIB23_RS29020 (PIB23_29020) 73096..73488 - 393 WP_001351729.1 isochorismatase family cysteine hydrolase -
PIB23_RS29025 (PIB23_29025) 73492..75243 + 1752 Protein_81 Tn3-like element TnAs1 family transposase -
PIB23_RS29030 (PIB23_29030) 75303..75569 + 267 WP_228733412.1 hypothetical protein -
PIB23_RS29035 (PIB23_29035) 75596..75775 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
PIB23_RS29040 (PIB23_29040) 75801..76229 - 429 WP_001140599.1 hypothetical protein -
PIB23_RS29045 (PIB23_29045) 76393..76707 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB23_RS29050 (PIB23_29050) 76695..76973 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
PIB23_RS29055 (PIB23_29055) 77148..77513 - 366 WP_072354022.1 TonB family protein -
PIB23_RS29060 (PIB23_29060) 77510..77881 - 372 WP_001237044.1 cell envelope integrity protein TolA -
PIB23_RS29065 (PIB23_29065) 78155..78400 - 246 WP_032440458.1 hypothetical protein -
PIB23_RS29070 (PIB23_29070) 79045..80532 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA14 / sul2 / tet(A) / blaLAP-2 / qnrS1 - 1..100630 100630


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T268805 WP_071177730.1 NZ_CP116493:c76707-76393 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT268805 WP_000093040.1 NZ_CP116493:c76973-76695 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References