Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4963471..4963987 Replicon chromosome
Accession NZ_CP116491
Organism Klebsiella pneumoniae strain XY05-03

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag PIB23_RS24765 Protein ID WP_002886902.1
Coordinates 4963471..4963755 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PIB23_RS24770 Protein ID WP_002886901.1
Coordinates 4963745..4963987 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB23_RS24740 (PIB23_24740) 4958955..4959218 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
PIB23_RS24745 (PIB23_24745) 4959348..4959521 + 174 WP_002886906.1 hypothetical protein -
PIB23_RS24750 (PIB23_24750) 4959524..4960267 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PIB23_RS24755 (PIB23_24755) 4960624..4962762 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
PIB23_RS24760 (PIB23_24760) 4963003..4963467 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PIB23_RS24765 (PIB23_24765) 4963471..4963755 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PIB23_RS24770 (PIB23_24770) 4963745..4963987 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PIB23_RS24775 (PIB23_24775) 4964065..4965975 - 1911 WP_004152270.1 PRD domain-containing protein -
PIB23_RS24780 (PIB23_24780) 4965998..4967152 - 1155 WP_002886900.1 lactonase family protein -
PIB23_RS24785 (PIB23_24785) 4967218..4967958 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T268799 WP_002886902.1 NZ_CP116491:c4963755-4963471 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT268799 WP_002886901.1 NZ_CP116491:c4963987-4963745 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References