Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 1332282..1332871 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag BV187_RS06585 Protein ID WP_005653200.1
Coordinates 1332282..1332530 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag BV187_RS06590 Protein ID WP_005653201.1
Coordinates 1332527..1332871 (+) Length 115 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS06560 (BV187_1329) 1327762..1328394 + 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -
BV187_RS06565 (BV187_1330) 1328396..1329022 + 627 WP_012054430.1 energy-coupling factor ABC transporter ATP-binding protein -
BV187_RS06570 (BV187_1331) 1329129..1330319 - 1191 WP_005657030.1 amino acid aminotransferase -
BV187_RS06575 (BV187_1332) 1330459..1331547 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BV187_RS06580 (BV187_1333) 1331617..1332111 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BV187_RS06585 (BV187_1334) 1332282..1332530 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
BV187_RS06590 (BV187_1335) 1332527..1332871 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BV187_RS06595 (BV187_1336) 1332915..1335524 + 2610 WP_012054428.1 aminopeptidase N -
BV187_RS06600 (BV187_1337) 1335596..1336210 - 615 WP_005657019.1 riboflavin synthase -
BV187_RS06605 (BV187_1338) 1336254..1337648 + 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(20-81)

Antitoxin

(54-102)


Sequences


Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T268786 WP_005653200.1 NZ_CP116490:1332282-1332530 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp


Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT268786 WP_005653201.1 NZ_CP116490:1332527-1332871 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03


Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References