Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1043372..1044003 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag BV187_RS05190 Protein ID WP_005651560.1
Coordinates 1043372..1043770 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag BV187_RS05195 Protein ID WP_005648011.1
Coordinates 1043770..1044003 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS05170 (BV187_1048) 1038556..1039674 + 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
BV187_RS05175 (BV187_1049) 1039675..1040697 + 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
BV187_RS05180 (BV187_1050) 1040771..1041586 - 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
BV187_RS05185 (BV187_1051) 1041817..1043352 - 1536 WP_012054543.1 L-2,4-diaminobutyrate decarboxylase -
BV187_RS05190 (BV187_1052) 1043372..1043770 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
BV187_RS05195 (BV187_1053) 1043770..1044003 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BV187_RS05200 (BV187_1054) 1044150..1045514 - 1365 WP_005664172.1 diaminobutyrate--2-oxoglutarate transaminase -
BV187_RS05205 (BV187_1055) 1045861..1046031 - 171 WP_005613503.1 50S ribosomal protein L33 -
BV187_RS05210 (BV187_1056) 1046043..1046279 - 237 WP_005542826.1 50S ribosomal protein L28 -
BV187_RS05215 (BV187_1057) 1046492..1047157 - 666 WP_041174703.1 DNA repair protein RadC -
BV187_RS05220 (BV187_1058) 1047321..1048523 + 1203 WP_012054541.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T268785 WP_005651560.1 NZ_CP116490:c1043770-1043372 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT268785 WP_005648011.1 NZ_CP116490:c1044003-1043770 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References