Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1014475..1015009 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name relE Uniprot ID A0A2R3GCN3
Locus tag BV187_RS05040 Protein ID WP_005651512.1
Coordinates 1014475..1014765 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID E7A5Y2
Locus tag BV187_RS05045 Protein ID WP_005651514.1
Coordinates 1014755..1015009 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS05015 (BV187_1016) 1011677..1012180 + 504 WP_005659127.1 LPS assembly lipoprotein LptE -
BV187_RS05020 (BV187_1017) 1012180..1013214 + 1035 WP_005659128.1 DNA polymerase III subunit delta -
BV187_RS05025 (BV187_1018) 1013393..1013695 + 303 WP_272524418.1 hypothetical protein -
BV187_RS05030 (BV187_1019) 1013878..1014015 - 138 WP_005659136.1 hypothetical protein -
BV187_RS05035 (BV187_1021) 1014185..1014439 - 255 WP_014551014.1 hypothetical protein -
BV187_RS05040 (BV187_1022) 1014475..1014765 - 291 WP_005651512.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV187_RS05045 (BV187_1023) 1014755..1015009 - 255 WP_005651514.1 stability protein StbD Antitoxin
BV187_RS05050 (BV187_1024) 1015307..1015531 - 225 WP_005659141.1 hypothetical protein -
BV187_RS05055 (BV187_1025) 1015531..1015839 - 309 WP_005659142.1 P2 family phage major capsid protein -
BV187_RS05060 (BV187_1026) 1015869..1016408 - 540 WP_005659144.1 hypothetical protein -
BV187_RS05070 (BV187_1028) 1016770..1018836 - 2067 WP_005686190.1 glycine--tRNA ligase subunit beta -
BV187_RS05075 (BV187_1029) 1019174..1019539 - 366 WP_005686191.1 endonuclease domain-containing protein -
BV187_RS05080 (BV187_1030) 1019569..1019829 - 261 WP_005663579.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11482.41 Da        Isoelectric Point: 10.6484

>T268784 WP_005651512.1 NZ_CP116490:c1014765-1014475 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSVGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9419.78 Da        Isoelectric Point: 4.0737

>AT268784 WP_005651514.1 NZ_CP116490:c1015009-1014755 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELGRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3GCN3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2QYX4

References