Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 721157..721805 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag BV187_RS03590 Protein ID WP_005694481.1
Coordinates 721446..721805 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag BV187_RS03585 Protein ID WP_005650837.1
Coordinates 721157..721453 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS03560 (BV187_0724) 716431..717189 - 759 WP_012054646.1 DUF3800 domain-containing protein -
BV187_RS03565 (BV187_0725) 717201..718007 - 807 WP_012054645.1 shikimate dehydrogenase -
BV187_RS03570 (BV187_0726) 718011..718562 - 552 WP_012054644.1 Sua5/YciO/YrdC/YwlC family protein -
BV187_RS03575 (BV187_0727) 718578..719114 - 537 WP_012054643.1 type I DNA topoisomerase -
BV187_RS03580 (BV187_0728) 719124..721040 - 1917 WP_012054642.1 ABC transporter ATP-binding protein -
BV187_RS03585 (BV187_0729) 721157..721453 - 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
BV187_RS03590 (BV187_0730) 721446..721805 - 360 WP_005694481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BV187_RS03595 (BV187_0731) 722075..725194 - 3120 Protein_665 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
BV187_RS03600 725152..725310 - 159 WP_272524520.1 PT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T268781 WP_005694481.1 NZ_CP116490:c721805-721446 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT268781 WP_005650837.1 NZ_CP116490:c721453-721157 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JUP0

Antitoxin

Source ID Structure

References