Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 526894..527231 Replicon chromosome
Accession NZ_CP116490
Organism Haemophilus influenzae strain 93P10H1

Toxin (Protein)


Gene name VapD Uniprot ID A0A2R3FLH7
Locus tag BV187_RS02570 Protein ID WP_005686917.1
Coordinates 526894..527031 (-) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag BV187_RS02575 Protein ID WP_005649350.1
Coordinates 527040..527231 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV187_RS02550 (BV187_0520) 522085..523755 - 1671 WP_005686908.1 fructose-specific PTS transporter subunit EIIC -
BV187_RS02555 (BV187_0521) 523757..524698 - 942 WP_005686910.1 1-phosphofructokinase -
BV187_RS02560 (BV187_0522) 524700..526199 - 1500 WP_005686912.1 fused PTS fructose transporter subunit IIA/HPr protein -
BV187_RS02565 (BV187_0523) 526271..526801 - 531 WP_005686915.1 hypothetical protein -
BV187_RS02570 (BV187_0524) 526894..527031 - 138 WP_005686917.1 hypothetical protein Toxin
BV187_RS02575 (BV187_0525) 527040..527231 - 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
BV187_RS02580 (BV187_0526) 527303..528601 - 1299 WP_032821624.1 hemolysin family protein -
BV187_RS02585 (BV187_0527) 528652..529176 - 525 WP_005686921.1 DUF1523 family protein -
BV187_RS02590 (BV187_0528) 529203..529985 - 783 WP_005686923.1 YchF/TatD family DNA exonuclease -
BV187_RS02595 (BV187_0529) 530040..531023 - 984 WP_005686925.1 DNA polymerase III subunit delta' -
BV187_RS02600 (BV187_0530) 531020..531652 - 633 WP_005686927.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5415.04 Da        Isoelectric Point: 4.4640

>T268780 WP_005686917.1 NZ_CP116490:c527031-526894 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

>T268780 NZ_CP116490:c527031-526894 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGCGTTCAAGAGGCTTATACAGA
CATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT268780 WP_005649350.1 NZ_CP116490:c527231-527040 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT268780 NZ_CP116490:c527231-527040 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTTGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTGAATATCACATTGTTACAATCTGGTGAAAAAGACATTTATCGCTTAT
CTCACCTACTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R3FLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References