Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1332317..1332906 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name hicA Uniprot ID Q4QL51
Locus tag BV189_RS06590 Protein ID WP_005653200.1
Coordinates 1332317..1332565 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q4QL50
Locus tag BV189_RS06595 Protein ID WP_005653201.1
Coordinates 1332562..1332906 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS06565 (BV189_1334) 1327797..1328429 + 633 WP_011272461.1 energy-coupling factor transporter transmembrane protein EcfT -
BV189_RS06570 (BV189_1335) 1328431..1329057 + 627 WP_012054430.1 energy-coupling factor ABC transporter ATP-binding protein -
BV189_RS06575 (BV189_1336) 1329164..1330354 - 1191 WP_005657030.1 amino acid aminotransferase -
BV189_RS06580 (BV189_1337) 1330494..1331582 - 1089 WP_005686592.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BV189_RS06585 (BV189_1338) 1331652..1332146 - 495 WP_005653194.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BV189_RS06590 (BV189_1339) 1332317..1332565 + 249 WP_005653200.1 type II toxin-antitoxin system HicA family toxin Toxin
BV189_RS06595 (BV189_1340) 1332562..1332906 + 345 WP_005653201.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BV189_RS06600 (BV189_1341) 1332950..1335559 + 2610 WP_012054428.1 aminopeptidase N -
BV189_RS06605 (BV189_1342) 1335631..1336245 - 615 WP_005657019.1 riboflavin synthase -
BV189_RS06610 (BV189_1343) 1336289..1337683 + 1395 WP_005657016.1 sodium-coupled multidrug efflux MATE transporter HmrM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9425.93 Da        Isoelectric Point: 10.4673

>T268777 WP_005653200.1 NZ_CP116489:1332317-1332565 [Haemophilus influenzae]
MGRTEKLLDKLAQSKSTFNWNELVSLLAQQGYEKREMAGSRVRFYNRTLEHTILLHKPHPENYIKGGALKSVKESLKQVG
IL

Download         Length: 249 bp

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13142.04 Da        Isoelectric Point: 4.8151

>AT268777 WP_005653201.1 NZ_CP116489:1332562-1332906 [Haemophilus influenzae]
MKLLNYKGYVGTIEADLENNILFGKLAYIRDLVTYEAESLSELEKEFRQSVDLYLQDCLELGKEPNKPFKGVFNVRIGEE
LHREATIIAGDRSLNAFVTEAIQEKIFREKPSLR

Download         Length: 345 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M6BP03

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GMF9

References