Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1043406..1044037 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag BV189_RS05195 Protein ID WP_005651560.1
Coordinates 1043406..1043804 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag BV189_RS05200 Protein ID WP_005648011.1
Coordinates 1043804..1044037 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS05175 (BV189_1052) 1038590..1039708 + 1119 WP_005686201.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
BV189_RS05180 (BV189_1053) 1039709..1040731 + 1023 WP_005651554.1 outer membrane-stress sensor serine endopeptidase DegS -
BV189_RS05185 (BV189_1054) 1040805..1041620 - 816 WP_012054544.1 DNA-formamidopyrimidine glycosylase -
BV189_RS05190 (BV189_1055) 1041851..1043386 - 1536 WP_012054543.1 L-2,4-diaminobutyrate decarboxylase -
BV189_RS05195 (BV189_1056) 1043406..1043804 - 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
BV189_RS05200 (BV189_1057) 1043804..1044037 - 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
BV189_RS05205 (BV189_1058) 1044184..1045548 - 1365 WP_005664172.1 diaminobutyrate--2-oxoglutarate transaminase -
BV189_RS05210 (BV189_1059) 1045895..1046065 - 171 WP_005613503.1 50S ribosomal protein L33 -
BV189_RS05215 (BV189_1060) 1046077..1046313 - 237 WP_005542826.1 50S ribosomal protein L28 -
BV189_RS05220 (BV189_1061) 1046526..1047191 - 666 WP_041174703.1 DNA repair protein RadC -
BV189_RS05225 (BV189_1062) 1047355..1048557 + 1203 WP_012054541.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T268776 WP_005651560.1 NZ_CP116489:c1043804-1043406 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT268776 WP_005648011.1 NZ_CP116489:c1044037-1043804 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References