Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 783937..784541 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name relE Uniprot ID A0A112W1Q1
Locus tag BV189_RS03880 Protein ID WP_005661261.1
Coordinates 784233..784541 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Y7JSS2
Locus tag BV189_RS03875 Protein ID WP_005661259.1
Coordinates 783937..784233 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS03860 (BV189_0788) 779703..781088 + 1386 WP_012054619.1 L-seryl-tRNA(Sec) selenium transferase -
BV189_RS03865 (BV189_0789) 781085..782944 + 1860 WP_012054618.1 selenocysteine-specific translation elongation factor -
BV189_RS03870 (BV189_0790) 782963..783817 + 855 WP_005687862.1 DUF3298 domain-containing protein -
BV189_RS03875 (BV189_0791) 783937..784233 + 297 WP_005661259.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BV189_RS03880 (BV189_0792) 784233..784541 + 309 WP_005661261.1 type II toxin-antitoxin system YafQ family toxin Toxin
BV189_RS03885 (BV189_0793) 784597..787964 - 3368 Protein_722 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(7-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11895.63 Da        Isoelectric Point: 7.3189

>T268774 WP_005661261.1 NZ_CP116489:784233-784541 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIHCLLNRLPLPENYQDHALVGEWKGYRDCHIQGDLVLIYQYV
IQDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11015.37 Da        Isoelectric Point: 4.4297

>AT268774 WP_005661259.1 NZ_CP116489:783937-784233 [Haemophilus influenzae]
MALTNSSISFRTVEKTKLEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A112W1Q1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Y7JSS2

References