Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 400084..400721 Replicon chromosome
Accession NZ_CP116489
Organism Haemophilus influenzae strain 93P28H1

Toxin (Protein)


Gene name VapC1 Uniprot ID A0A0Y7JDC3
Locus tag BV189_RS01915 Protein ID WP_005659980.1
Coordinates 400317..400721 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID A0A0H3PN67
Locus tag BV189_RS01910 Protein ID WP_005656316.1
Coordinates 400084..400320 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BV189_RS01885 395292..395573 + 282 Protein_338 hypothetical protein -
BV189_RS01890 (BV189_0390) 395776..396648 - 873 WP_048954586.1 hypothetical protein -
BV189_RS01895 (BV189_0391) 396710..398476 - 1767 WP_011961734.1 aspartate--tRNA ligase -
BV189_RS01900 (BV189_0392) 398695..399213 + 519 WP_005649040.1 isoprenylcysteine carboxyl methyltransferase family protein -
BV189_RS01905 (BV189_0393) 399266..399991 + 726 WP_005669008.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
BV189_RS01910 (BV189_0394) 400084..400320 + 237 WP_005656316.1 antitoxin Antitoxin
BV189_RS01915 (BV189_0395) 400317..400721 + 405 WP_005659980.1 type II toxin-antitoxin system VapC family toxin Toxin
BV189_RS01920 (BV189_0396) 400788..401195 + 408 WP_005654069.1 lactoylglutathione lyase -
BV189_RS01925 (BV189_0397) 401269..401958 + 690 WP_005686760.1 ribonuclease T -
BV189_RS01930 (BV189_0398) 402274..403626 + 1353 WP_005686762.1 Na+/H+ antiporter family protein -
BV189_RS01935 (BV189_0399) 403658..404242 + 585 WP_005686764.1 primosomal replication protein -
BV189_RS01945 (BV189_0401) 404594..405160 - 567 WP_005544066.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15660.23 Da        Isoelectric Point: 8.9777

>T268770 WP_005659980.1 NZ_CP116489:400317-400721 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIVAERVSQLLPNDRLVISFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9007.16 Da        Isoelectric Point: 4.2342

>AT268770 WP_005656316.1 NZ_CP116489:400084-400320 [Haemophilus influenzae]
MLAKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JDC3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3PN67

References