26877

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3764014..3764543 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag CCDC5180_RS17785 Protein ID WP_003417760.1
Coordinates 3764286..3764543 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag CCDC5180_RS17780 Protein ID WP_003417757.1
Coordinates 3764014..3764289 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS22935 3760812..3762249 - 1438 Protein_3463 FAD-binding oxidoreductase -
CCDC5180_RS17765 3762352..3762741 + 390 WP_003417745.1 DUF732 domain-containing protein -
CCDC5180_RS17770 3762755..3763048 - 294 WP_003417749.1 DUF3017 domain-containing protein -
CCDC5180_RS17775 3763045..3763890 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
CCDC5180_RS17780 3764014..3764289 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
CCDC5180_RS17785 3764286..3764543 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
CCDC5180_RS17790 3764585..3765775 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
CCDC5180_RS17795 3765892..3766260 + 369 WP_003417765.1 FHA domain-containing protein -
CCDC5180_RS17800 3766257..3766808 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
CCDC5180_RS17805 3766815..3767396 - 582 WP_003417769.1 ATP/GTP-binding protein -
CCDC5180_RS17810 3767377..3767745 - 369 WP_003417772.1 DUF742 domain-containing protein -
CCDC5180_RS17815 3767723..3768115 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T26877 WP_003417760.1 NC_017522:3764286-3764543 [Mycobacterium tuberculosis CCDC5180]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T26877 NC_017522:3764286-3764543 [Mycobacterium tuberculosis CCDC5180]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT26877 WP_003417757.1 NC_017522:3764014-3764289 [Mycobacterium tuberculosis CCDC5180]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT26877 NC_017522:3764014-3764289 [Mycobacterium tuberculosis CCDC5180]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
AlphaFold DB G0TI94

References