Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3695233..3695907 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag CCDC5180_RS17565 Protein ID WP_003417282.1
Coordinates 3695233..3695661 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag CCDC5180_RS17570 Protein ID WP_003417286.1
Coordinates 3695665..3695907 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS17540 3691055..3691456 - 402 WP_003417264.1 cytidine deaminase -
CCDC5180_RS17545 3691597..3692031 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
CCDC5180_RS17550 3692028..3692462 + 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
CCDC5180_RS17555 3692591..3694363 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
CCDC5180_RS17560 3694363..3695154 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
CCDC5180_RS17565 3695233..3695661 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
CCDC5180_RS17570 3695665..3695907 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
CCDC5180_RS17575 3696029..3696643 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
CCDC5180_RS17580 3696640..3697305 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
CCDC5180_RS17585 3697306..3697839 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
CCDC5180_RS17590 3697836..3698210 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
CCDC5180_RS17595 3698307..3699371 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T26876 WP_003417282.1 NC_017522:c3695661-3695233 [Mycobacterium tuberculosis CCDC5180]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T26876 NC_017522:c3695661-3695233 [Mycobacterium tuberculosis CCDC5180]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT26876 WP_003417286.1 NC_017522:c3695907-3695665 [Mycobacterium tuberculosis CCDC5180]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT26876 NC_017522:c3695907-3695665 [Mycobacterium tuberculosis CCDC5180]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References