Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3633541..3634136 Replicon chromosome
Accession NZ_CP116480
Organism Escherichia coli strain GTEN_24

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag E5Q65_RS17550 Protein ID WP_000239579.1
Coordinates 3633786..3634136 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag E5Q65_RS17545 Protein ID WP_001223208.1
Coordinates 3633541..3633792 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Q65_RS17535 (3629205) 3629205..3632984 + 3780 WP_000060921.1 autotransporter assembly complex protein TamB -
E5Q65_RS17540 (3632987) 3632987..3633328 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
E5Q65_RS17545 (3633541) 3633541..3633792 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
E5Q65_RS17550 (3633786) 3633786..3634136 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
E5Q65_RS17555 (3634216) 3634216..3634746 - 531 WP_000055070.1 inorganic diphosphatase -
E5Q65_RS17560 (3635056) 3635056..3636012 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
E5Q65_RS17565 (3636152) 3636152..3637654 + 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
E5Q65_RS17570 (3637668) 3637668..3638690 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T268756 WP_000239579.1 NZ_CP116480:3633786-3634136 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT268756 WP_001223208.1 NZ_CP116480:3633541-3633792 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References