Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1224259..1225090 Replicon chromosome
Accession NZ_CP116480
Organism Escherichia coli strain GTEN_24

Toxin (Protein)


Gene name yeeV Uniprot ID F4THW6
Locus tag E5Q65_RS06145 Protein ID WP_000854818.1
Coordinates 1224716..1225090 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID F4THW5
Locus tag E5Q65_RS06140 Protein ID WP_001313071.1
Coordinates 1224259..1224627 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E5Q65_RS06105 (1219485) 1219485..1220555 + 1071 WP_000102643.1 patatin-like phospholipase family protein -
E5Q65_RS06110 (1220691) 1220691..1221374 + 684 WP_042004735.1 hypothetical protein -
E5Q65_RS06115 (1221390) 1221390..1221800 + 411 WP_000846713.1 hypothetical protein -
E5Q65_RS06120 (1222021) 1222021..1222842 + 822 WP_001234530.1 DUF932 domain-containing protein -
E5Q65_RS06125 (1222924) 1222924..1223403 + 480 WP_000860076.1 antirestriction protein -
E5Q65_RS06130 (1223419) 1223419..1223895 + 477 WP_001186726.1 RadC family protein -
E5Q65_RS06135 (1223958) 1223958..1224179 + 222 WP_000692301.1 DUF987 domain-containing protein -
E5Q65_RS06140 (1224259) 1224259..1224627 + 369 WP_001313071.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E5Q65_RS06145 (1224716) 1224716..1225090 + 375 WP_000854818.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
E5Q65_RS06150 (1225087) 1225087..1225281 + 195 WP_000988600.1 DUF5983 family protein -
E5Q65_RS06155 (1225327) 1225327..1225407 + 81 Protein_1207 hypothetical protein -
E5Q65_RS06160 (1225616) 1225616..1227157 + 1542 WP_001298859.1 IS21-like element ISEc12 family transposase -
E5Q65_RS06165 (1227172) 1227172..1227918 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
E5Q65_RS06170 (1228282) 1228282..1228362 - 81 WP_023441679.1 hypothetical protein -
E5Q65_RS06175 (1228341) 1228341..1228664 + 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
E5Q65_RS06180 (1228765) 1228765..1229094 - 330 WP_000450409.1 DUF496 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13972.98 Da        Isoelectric Point: 7.1333

>T268747 WP_000854818.1 NZ_CP116480:1224716-1225090 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp


Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13498.23 Da        Isoelectric Point: 5.8696

>AT268747 WP_001313071.1 NZ_CP116480:1224259-1224627 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3W3PHA3


Antitoxin

Source ID Structure
AlphaFold DB A0A1M1L2Z3

References