Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 3506464..3507206 Replicon chromosome
Accession NZ_CP116477
Organism Pectobacterium sp. A5351

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag O1Q74_RS16185 Protein ID WP_271874631.1
Coordinates 3506464..3506943 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6P1S083
Locus tag O1Q74_RS16190 Protein ID WP_039481848.1
Coordinates 3506934..3507206 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q74_RS16155 (O1Q74_16155) 3502215..3502502 - 288 WP_271874629.1 RnfH family protein -
O1Q74_RS16160 (O1Q74_16160) 3502483..3502929 - 447 WP_271874630.1 type II toxin-antitoxin system RatA family toxin -
O1Q74_RS16165 (O1Q74_16165) 3503085..3503567 + 483 WP_012773422.1 SsrA-binding protein SmpB -
O1Q74_RS16175 (O1Q74_16175) 3504093..3504958 + 866 Protein_3136 IS3 family transposase -
O1Q74_RS16180 (O1Q74_16180) 3504968..3506179 - 1212 Protein_3137 IS3 family transposase -
O1Q74_RS16185 (O1Q74_16185) 3506464..3506943 - 480 WP_271874631.1 GNAT family N-acetyltransferase Toxin
O1Q74_RS16190 (O1Q74_16190) 3506934..3507206 - 273 WP_039481848.1 DUF1778 domain-containing protein Antitoxin
O1Q74_RS16195 (O1Q74_16195) 3507505..3507681 + 177 WP_271874632.1 hypothetical protein -
O1Q74_RS16200 (O1Q74_16200) 3508082..3508306 + 225 Protein_3141 transposase -
O1Q74_RS16205 (O1Q74_16205) 3509014..3509214 + 201 WP_271874633.1 hypothetical protein -
O1Q74_RS16210 (O1Q74_16210) 3509290..3509862 - 573 WP_271874634.1 TetR/AcrR family transcriptional regulator -
O1Q74_RS16215 (O1Q74_16215) 3510362..3510457 + 96 Protein_3144 SDR family oxidoreductase -
O1Q74_RS16220 (O1Q74_16220) 3510520..3511626 + 1107 WP_271874635.1 NADH:flavin oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3499646..3509214 9568
- inside IScluster/Tn - - 3504968..3508357 3389


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-146)

Antitoxin

Vibrio phage ICP1, Orf50

(3-90)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17486.18 Da        Isoelectric Point: 9.5963

>T268730 WP_271874631.1 NZ_CP116477:c3506943-3506464 [Pectobacterium sp. A5351]
VGITAPELLLPQHAVVDFRSSEPSLDDWLKRKALKNQTIGASRTFIVCESGANQVIGFYALATGSVQRQSVSGALRRNMP
DPLPVLVLGRLAVDERYQRRGIGAGLLKDAILRSRQVAEQVGTKALLVHALSEEAKDFYLHWGFTPSEIQPSTLLLPLW

Download         Length: 480 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10288.77 Da        Isoelectric Point: 4.7174

>AT268730 WP_039481848.1 NZ_CP116477:c3507206-3506934 [Pectobacterium sp. A5351]
MRTEAKEAPINIRAKSSQRELIDVAAKLLSKSRTDFILEAACREAEEVLLDQRLFLVDESQFDAFITALEKPVATNERLQ
ALLDRKSPWE

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S083

References