Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3158378..3158926 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag CCDC5180_RS15115 Protein ID WP_003414602.1
Coordinates 3158663..3158926 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag CCDC5180_RS15110 Protein ID WP_003414599.1
Coordinates 3158378..3158659 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS15085 3154002..3154859 - 858 WP_003899513.1 type I methionyl aminopeptidase -
CCDC5180_RS15090 3154901..3155485 - 585 WP_003414585.1 DUF1707 domain-containing protein -
CCDC5180_RS15095 3155588..3155836 + 249 WP_003913411.1 antitoxin VapB23 -
CCDC5180_RS15100 3155833..3156213 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
CCDC5180_RS15105 3156295..3158106 - 1812 WP_003414596.1 penicillin-binding protein -
CCDC5180_RS15110 3158378..3158659 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
CCDC5180_RS15115 3158663..3158926 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCDC5180_RS15120 3159299..3160153 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
CCDC5180_RS15125 3160209..3161372 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
CCDC5180_RS15130 3161389..3162603 - 1215 WP_003414610.1 zinc metalloprotease Rip -
CCDC5180_RS15135 3162611..3163852 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T26873 WP_003414602.1 NC_017522:3158663-3158926 [Mycobacterium tuberculosis CCDC5180]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T26873 NC_017522:3158663-3158926 [Mycobacterium tuberculosis CCDC5180]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT26873 WP_003414599.1 NC_017522:3158378-3158659 [Mycobacterium tuberculosis CCDC5180]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT26873 NC_017522:3158378-3158659 [Mycobacterium tuberculosis CCDC5180]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References