Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2638684..2639237 Replicon chromosome
Accession NZ_CP116477
Organism Pectobacterium sp. A5351

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag O1Q74_RS12355 Protein ID WP_271873538.1
Coordinates 2638684..2638998 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3S1FM98
Locus tag O1Q74_RS12360 Protein ID WP_029729596.1
Coordinates 2639001..2639237 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q74_RS12325 (O1Q74_12325) 2634242..2634514 - 273 WP_271873534.1 hypothetical protein -
O1Q74_RS12330 (O1Q74_12330) 2634730..2636118 - 1389 WP_271873535.1 ATP-binding protein -
O1Q74_RS12335 (O1Q74_12335) 2636118..2636795 - 678 WP_271873536.1 response regulator -
O1Q74_RS12340 (O1Q74_12340) 2637000..2637836 + 837 WP_271873537.1 MipA/OmpV family protein -
O1Q74_RS12345 (O1Q74_12345) 2638023..2638205 - 183 Protein_2390 IS630 family transposase -
O1Q74_RS12350 (O1Q74_12350) 2638255..2638650 + 396 Protein_2391 molybdopterin-guanine dinucleotide biosynthesis protein MobC -
O1Q74_RS12355 (O1Q74_12355) 2638684..2638998 - 315 WP_271873538.1 CcdB family protein Toxin
O1Q74_RS12360 (O1Q74_12360) 2639001..2639237 - 237 WP_029729596.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
O1Q74_RS12365 (O1Q74_12365) 2639419..2639535 + 117 Protein_2394 IS110 family transposase -
O1Q74_RS12370 (O1Q74_12370) 2640010..2640726 + 717 WP_271873539.1 4'-phosphopantetheinyl transferase superfamily protein -
O1Q74_RS12375 (O1Q74_12375) 2640872..2642029 - 1158 Protein_2396 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2630708..2649633 18925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11549.50 Da        Isoelectric Point: 7.9859

>T268725 WP_271873538.1 NZ_CP116477:c2638998-2638684 [Pectobacterium sp. A5351]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAALDFLIDGF

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8927.96 Da        Isoelectric Point: 6.4612

>AT268725 WP_029729596.1 NZ_CP116477:c2639237-2639001 [Pectobacterium sp. A5351]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRSHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S1FM98

References